The present study discussed the relevance of economic statecraft and defense supply chain security for enhancing Indo-Pacific strategic partnership between the two countries – India and Australia. The mixed-method approach adopted meant that the qualitative and quantitative methods were used, the data was gathered from 150 strategic affairs experts using a structured questionnaire. Data obtained were analysed descriptively, correlation and regression using MS Excel and SPSS 27. The results showed that there was a strong positive correlation between the initiatives of economic statecraft and Indo–Australia strategic cooperation, and defense supply chain security also had a significant contribution to Indo–Pacific strategic resilience. The study emphasized the need for regional cooperation in critical minerals, emerging technologies, defense industries, and resilient supply chains to boost regional security and minimize strategic vulnerabilities. It found that synergizing economic statecraft with secure supply chains for defence would help bolster bilateral cooperation, contribute to a free and open Indo-Pacific and serve as a useful policy learning opportunity for maximizing long-term regional stability and strategic resilience.