Gender equality means that women and men, girls and boys have equal conditions, treatment and opportunities for realizing their full potential, human rights and dignity, and for contributing to and benefitting from economic, social, cultural and political development. Gender equality is, therefore, the equal valuing by society of the similarities and the differences of men and women, and the roles they play. It is based on women and men being full partners in the home, community and society. Equality does not mean that women andmen will become the same but womens and mens becomes equal in rights, responsibilities and opportunities will not depend on whether they are born male or female. Gender equality implies that the interests, needs and priorities of both women and men and girls and boys aretaken into consideration, recognizing the diversity of different groups and that all human beings are free to develop their personal abilities and make choices without the limitations set by stereotypes and prejudices about gender roles. Gender equality is a matter of human rights and is considered a precondition for, and indicator of, sustainable people centred development. Gender equality is the process of being fair to men and women, boys and girls, and importantly the equality of outcomes and results. Gender equality may involve the use of temporary special measures to compensate for historical or systemic bias or discrimination. It refers to differential treatment that is fair and positively addresses a bias or disadvantage that is due to gender roles or norms or differences between the sexes. Equality ensures that women and men and girls and boys have an equal chance, not only at the starting point, but also when reaching the finishing line. It is about the fair and just treatment of both sexes that takes into account the different needs of the men and women, cultural barriers and discrimination of the specific group. When United Nations established gender equality programming came into existence. Important examples include gender mainstreaming, gender analysis, prevention and response to gender-based violence and sexual exploitation and abuse, promotion and protection of human rights, empowerment of women and girls and gender balance in the workplace. Gender programming response means paying attention to the unique needs of females, valuing their perspectives, respecting their experiences, understanding developmental differences between girls and boys, women and men and ultimately empowering girls and women. UN spread Human Rights Based Approach (HRBA) that is to empower people (rights holders) to realize their rights and strengthen the State to comply with their human rights obligations and duties. States obligations to human rights require them to respect, protect and fulfill women’s and girls rights, along with the rights of men and boys. When they fail to do so, the United Nations has a responsibility to work with partners to strengthen the capacity to more effectively realize that duty. This paper assess the United Nations Agenda, with a focus on its gender-related goals and objectives. This paper explores the key challenges in achieving the international goals and commitments in the area of gender equality and the empowerment of women. This paper critically analysed the initiatives of United Nations for gender equality.